Update-1..2/15/24…Post from 9/23 biotech bottom when we picked ABBV,GEHC. Near/at new 52 wk. highs : ABBV, LLY,  MRK, VRTX, XPH etc.

Update- -2/12/24….Gilead Sciences responds immediately to recent trial disappointment to buy CymaBay,a $4.3B deal expanding liver portfolio. See chart below as well.

IBB Chart

Large Cap Biopharmaceuticals

Our new market model envisions an increase in M&A by large cap biopharma to expand pipelines. Valuations remain attractive. But it’s a MOMENTUM driven market.

  • Growing divergence among winners and losers from Eli Liily (LLY) to Pfizer (PFE).
  • Gilead Sciences (GILD) hurt by late stage drug cancer trial failure.
  • Abbvie (ABBV) antes up investments in neuroscience.
  • No end to obesity drug  plays LLY,NOVO,AMGN.
  • Watch Amgen in coming months for data on AMG786 a obesity drug.
  • SMID biotech companies are in a bear market with the IBB flat over one year.
  1. Top Winners -One Year:  LLY, VRTX, REGN, AMGN, MRK,GSK, ABBV.
  2. Biggest Losers-One Year: PFE, BMY, GILD, AZN, BIIB.
  3. WINNERS YTD: LLY. MRK, ABBV, GSK, REGN,
  4. Pfizer is a contrarian turnaround play with new deals..

Long: ABBV,  GILD, LLY, MRK,PFE, REGN, VRTX

Company Ticker Price Price Price Price PRICE % Perf Price tech
1/15/18 3/31/23 11/1/19 10/8/2023 2024 YTD FWD Analyst % 52 week H 1 yr % 1/7/24 u/d 10/8
2/11/24 % Perf P/S PE Recom Div
Abbvie ABBV 100.000 159.37 81.75 148.23 174.08 12.33 5.66 14.28 1.89 3.58 175.4 17.07 162.14 u
Alexion*(ALXN) ALXN 123.000 182.5 109.38 40.33 n/a 4.56 9.38 n/a *acquired by AZN AZN
Amgen AMGN 185.000 241.75 221 263 291.12 1.08 5.43 13.68 2.31 3.18 329 21.3 303
AstraZeneca* AZN 35.000 69.41 40.34 67.42 62.26 -7.56 4.21 13.27 1.59 2.51 76.56 -7.65 68.38 d
Biogen BIIB 336.000 278.31 299.2 263.25 240.98 -6.87 3.63 15.24 1.55 319.76 -5.69 257.88 d
Bristol Myers* BMY 63.000 69.31 57.16 56.66 49.81 -2.92 2.25 6.99 2.58 4.93 75.18 -30.33 52.23 d
Celgene* (BMY) CELG 106.000 n/a 108.53 77 n/a 4.69 8.7 n/a
*acquired by BMY
Gilead Sci GILD 79.000 82.97 61.69 74.74 73.67 -9.06 3.39 9.78 2.19 4.28 88.29 -13.87 87.87 d
GlaxoSmithK* GSK 38.000 35.58 45 36.65 41.31 13.09 2.25 9.6 2.3 3.65 42.21 15.04 39.21 u
Eli Lilly LLY 85.000 343.42 113 565.22 740.16 26.97 20.59 41.48 1.7 0.71 745.7 116.55 618.55 u
Merck MRK 59.000 106.39 78 103.88 125.45 15 5.27 13 1.59 2.6 128 17.55 117.22 u
Pfizer PFE 40.8 33.13 27.56 -4.27 2.66 10.1 2.25 6.18 40.32 -36.41 29.47 d
Regeneron REGN 367.000 821.67 310.48 836.57 953.42 8.55 7.98 20.17 1.76 974 28 913 u
Vertex VRTX 158.000 315.07 196 360.62 422.91 3.94 11.08 22.89 2 422.91 45 416.5 u/-
3/31 11/19 10/7/23 2/11/24
%YTD
1/7/24
XBI 76.21 93 72.23 91.04 1.96 92.6 5.75 89.3 u
IBB 129.16 119.65 122.48 134.59 -0.93 139.41 1.65 136.12 u/-
FBIOX 15.63 20.26 15.47 18.7 4.88 18.7 14.65 17.93 u
PRHSX 87.75 79 86.37 93 5.92 93 4.91 88.33 u/-
XLV 129.46 121.11 1 144 5.59 145.03 9.72 139.12 u
XPH 41.01 39.47 39.05 43.83 5.31 44.31 2.17 44.31 u
UNH 472.59 252 524.81 518.22 -1.57 525.95 6.69 537.23 u/-
QQQ 320.93 201.23 364.7 437.05 6.72 387.98 44.87 396.75 u

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