Update-3 …10/17…Earnings Abbott (ABT) returns to growth in MEDTech: Raises EPS. a strong hold with DIV. of 1.88%.   United Health (UNH) a core holding in any healthcare portfolio navigates increasing medical costs and cyberattack. Updated at 11:30a 10/18.

Update-2 …10/16  3:40 EDT.….Quiet strength in SMID biotechs from the RAYNO Life Science Trading List. with the XBI back to the $100 level. 2% plus movers: CPRX, CRBU, CRMD, DNLI,  EXEL, RNA, NTLA,  RXRX, RZLT, TEM.

  • Looks like a little profit taking in one of our best stocks: NTRA down about 1.9% on lighter volume at $126 level.
  • NVAX down 19% to $10 on safety concern and FDA pause.
  • The volatility in some of these stocks is a little crazy so we need to flag select stocks like ADPT and PACB.

Update-1 …10/14…..DOW and S&P 500 hits fresh highs as large cap tech buying renews : AAPL, AMAT,QCOM, NVDA, etc.; MedTech perks up BDX,EW,GKOS, HOLX. Life science trades more green than red: ILMN,NTLA, TEM,TWST. XBI quiet at $99.

LONG ABT,ISRG,UNH.

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Longboard Pharmaceuticals (LBPH) up over 51% on Lundbeck $2.6B buyout. Late stage products in neuroscience.

  • Technology stocks continue to outperform with fits of Momentum from generative AI theme.
  • Healthcare sector lags despite moderate growth. Note bad news from CVS and Humana.
  • Momentum plays exist with specific stocks where innovation becomes apparent. e.g.CorMedix.

The market hit new highs last week led by technology and communication stocks as bull market enters 3rd Year.  Defensive stocks such as Healthcare (XLV) up 12.84% YTD, lagged while the Financials (XLF) up over 2%, up 21.84% YTD beat the S&P over the past week with strong earnings from banks. This week we will get a good feel for the healthcare sector from companies reporting such as Johnson and Johnson (JNJ) and United Health (UNH). The XLV is weighted heavily with five stocks LLY, UNH, JNJ ,ABBV and MRK. Over the past year we have focused on several large cap stocks with dividends: ABBV, LLY, REGN and VRTX. The top weighted MedTECH stocks in the XLV are: TMO, ABT, DHR and ISRG. You can get good diversification in the Tools and Device sector with 2 FUNDS the FSMEX up 8.88% YTD and PRHSX up 14.25 %YTD, as you can see performance of our top funds below.

Chars healthcare (XLV compared to technology (XLK)

Recent Trades:

  • We added shares of Pfizer (PFE) under $30 protected somewhat  by a yield of 5.76%. as activist investor Starboard came inasa disruptor but the legal fracas has not boosted the stock. Future product sales improvement is expected from the acquisition of Seagen.
  • We also bought shares of Illumina (ILMN) that has picked up momentum over the past two weeks from a number of upgrades with expectation of a strong  product refresh cycle. CEO and bad GRAIL deal is gone.

The IBB and XBI recovered from recent lows and the XBI is up 10% YTD which lags our best FUND picks. The IBB also trails up only 7% YTD but improving.

STOCKS to Watch based on monthly performance from our SMID Life Science focus list:

  1. CorMed (CRMD) up 46% MTD and 169% YTD.
  2. Illumina (ILMN) up 16% MTD and 7.45% YTD.
  3. PacificBioscience (PACB up 17.86% MTD and -80% YTD.
  4. Natera NTA) up 5% MTD, up107%YTD.
  5. Denali Therapeutics up 3.4% MTD, up 30.5% YTD.
  6. Adaptive Biotechnologies up 12.5% MTD, up 0.82% YTD.
  7. Catalyst Pharma (CPRX) up 3.8% MTD, up 20% YTD.
  8. Avidity Sciences (RNA)  up 15% MTD, 3.8% YTD.
  9. Crenetics (CRNX) up 4.7% TD, 49%YTD.

SMID CAP Trading List

10/13/24 %YTD %MTD
COMPANY Ticker ST
P P % P % % MCAP RSI Trend
P 1/20/23 Initial 2/4/23 12/24/23 YTD % 4/8/24 % 10/13/24 YTD MTD $B
Adaptive BiioTech ADPT 4.11 5 2.6 -46.94 4.94 0.82 12.53 0.728 52.59 d
Acumen Therap ABOS 5.29 3.57 -33.89 3.17 -17.45 2.35 -38.8 -4.86 0.141 44.3
Avidity Sciences RNA new 7/1/24 25 46.6 415 14.99 5.46 55
Catalyst Pharma CPRX 16.1 16.58 -10.86 14.89 11.42 20.2 20.17 3.8 2.4 53.8
Caribou Biosci CRBU 6.29 6.17 -0.175 3.71 -35.25 1.9 -66.8 -6.88 0.169 48.47
CorMedix CRMD 3.9 5.31 41.22 10.12 169 46.45 0.584 83.4 u
Crenetics CRNX 42.12 18.38 53.14 49.35 4.7 4.8 54.7
CRSPR Therap CRSP 49.61 -25 55.27 63.67 56.63 53.91 -13.88 46.85 -25.16 3.1 3.99 50.81 u
Cryoport CYRX 21.75 -42.34 25.24 16.09 -7.26 16.38 5.75 6.98 -54.94 -10.4 0.35 36.2 d
Cytokinetics CYTK 31 65.34 -21.74 54.98 -34.27 2.06 6.46 51.64
Denali DNLI 22 19.21 -9 28 30.48 3.4 4 51.93
Exelixis EXEL 22.25 23.75 -1.21 26.23 9.34 1.5 7.48 52
Evolent Health EVH 30.83 13.74 31.96 32.08 14.25 27.65 -16.29 27.06 -18.07 -10.25 3.15 44.59 u
Geron GERN 3.19 9.24 3.22 2.29 -5.37 3.79 79.62 4.33 105.21 -1.37 2.6 47.1
Humacyte HUMA new* 8/1/24 8.25 5.73 101.76 0.7 717 51.4
Ilumina ILMN new* 10/4/24 143 145.54 7.45 16.59 23.2 67.8 u
Intelllia NTLA 25.5 18.58 -39 -8.02 1.89 39.54
Immatics IMTX 9.3 9.9 13.66 10 -4.94 9.34 -11.03 20.1 0.96 26.65 d
Natera NTRA 60 91.66 46.33 130 107.63 5.03 16 57
Pacific Biosci PACB 11.29 55.68 11.58 8.59 5 1.47 -85 1.98 -79.9 17.86 0.539 61.9 u
Novavax NVAX 3.67 12.53 161 1.95 2 47.5
Quidel-Ortho QDEL new 9/16/24 44 41 -44.3 -8.47 2.76 37.75 d
Recursion Pharm RXRX 10.75 8.12 -17.65 6.62 -32.86 2.64 1.93 51.35
Rezolute RZLT new 7/8/24 4.25 4.7 373.3 -8.56 0.263 47.21
Roivant ROIV 11.4 11.03 -1.78 11.9 5.97 -3.88 8.8 5.1 u
Supernus SUPN 40.3 12.3 41.61 29.23 -18.05 30.07 3.9 33 14 (6.18 1.82 58.22 u
Tempest AI TEM new 7/10/24 52 48.82 21,29 5.01 7.53 47.39
Twist Biosci TWST 18 3.76 34.03 31.54 -14.53 44.47 20.65 0.25 2.61 51.31
10x Genomics TXG 47.84 56.58 55.27 27.59 -50.79 16.26 -70.94 -26.43 1.96 32.25 d
Vericel VCEL 31 34.75 31.93 46.05 29.32 41.89 17.07 -4.6 2.04 43.35
Veracyte VCYT 24.89 39.43 26.67 28.27 19.13 19.31 -29.81 34.02 23.66 12.2 2.61 57.2 u
SPDR Biotech XBI 86.99 14.75 90.39 87.62 5.57 83.49 -6.51 98.68 10.52 -0.22 51.91
iShares BIO IBB 133.77 -1.89 132.51 -2.48 145.59 7.17 53 u
HealthcareSPDR XLV 135.02 143.22 5.02 153.89 12.84 -0.9 52.53
iShares MedTEch IHI 53.65 57.3 6.17 55.79 58.61 8.6 -0.91 51.97
ArkGenomics ARKG 35.28 32.81 16.22 23.18 -29.35 24.79 -24.44 -2.13 52.96
T.RowePrice PRHSX 86.84 -3.32 92.49 5.22 100.4 14.22 -0.32
FidoSelBiotech FBIOX 1763 21.42 20.13 1.04
FIdoMedTech FSMEX 61.77 64.23 67.46 8.88
JANUS Life Sci JNGLX 80.72 \16.77 -0.28
12/24/23 8/12/24 %YTD MTD
iShares CoreS&P IJR 108.34 14.48 107.62 -0.58 109.6 1.32 -1.54
iShares Russell IWM 201.48 15.55 204.45 1.86 205.86 2.55 -3.53
NASDAQ-100 QQQ 408.38 53.36 440.47 7.56 453.19 10.7 -8.42
Fido MED Tech FSMEX 61.77 63.36 2.26 0.19
T.RowePrice PRHSX 86.84 -3.32 92.49 5.22 97.33 10.73 -1.1
iShares MED Dev IHI 53.65 2.05 57.3 6.17 55.79 3.37 -1.19

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